Genomic Services
XING Genomic Services is an Australian company providing an extensive range of molecular biology laboratory services to support preclinical/clinical trial studies, including full customized assay validation in specialized areas of clinical cancer sequencing and biodistribution studies. Our laboratory services are performed under National Association of Testing Authorities, Australia (NATA) AS ISO 15189-certified. This ensures our quality management systems and competence assessment of our molecular biology team are held to a worldwide-recognized standard, therefore providing our clients trust in the quality of our services.
Next Generation Sequencing (NGS) for Homologous Recombination deficiency (HRD
- The EMBRACE Study: Phase II clinical trial of the PARP inhibitor, Olaparib, in HR-deficient metastatic breast and relapsed ovarian cancer
- NGS testing for SNP/Indels, copy number, and promoter methylation
50% BRCA1/RAD51C promoter methylation.
“XING has been a fantastic partner to work with on the Embrace trial. They have provided a smooth process for screening, from test request to final reports. I would recommend XING without reservation for future clinical trials.”
Biodistribution/Excretion Testing
- A placebo-controlled, non-clinical toxicity mouse study entailing administration of an adenovirus vector-based test item
- Sample extraction and qPCR assays to quantify the adenovirus vector DNA in tissue, stool and urine are developed and validated
Biodistribution analyses in mice via intramuscular (Top) and intranasal (Bottom) dose administration.
“I really appreciate XING’s prompt and e ective communication throughout to ensure our study objectives are met. They delivered testing data of excellent quality and integrity to provide us trust in their services. I would highly recommend XING for the quality service they provide and would be happy to partner with them again for future studies.”
Sample Processing
- DNA/RNA/protein extraction from a diverse range of sample matrices such as solid tissues, cultured cells, swabs, stools and various biofluids (eg. blood, urine, wastewater)
- Extracted DNA/RNA quantification, quality assessment, and fragment size analysis
DNA/RNA Analysis
- Biomarker level quantification via real-time PCR
- DNA/RNA sequencing
- Gene expression assessment
- Copy number variation
- Genotyping
Customized Assay Qualification/Validation
- Primer/probe design using in-house bioinformatics pipeline
- Sourcing of commercially available assay kits and fit-for-purpose verification
- Primer/probe testing and optimization for DNA/RNA biotargets
- Stringent assay design, validation and transfer workflow
Immunoassay Bioanalysis
- ELISA
- Western blot
- SDS-PAGE
- Sourcing of commercially available antibodies and fit-for-purpose immunoassay verification
- Primer/probe design using in-house bioinformatics pipeline
- Sourcing of commercially available assay kits and fit-for-purpose verification
- Primer/probe testing and optimization for DNA/RNA biotargets
- Stringent assay design, validation and transfer workflow
Service Support
- Experienced team with a proven track record in scientific technical proficiencies and project management
- Rapid generation of laboratory service scope and budget for consideration
- Prompt and responsive communication
- Punctual delivery of service deliverables within budget
- Quality compliant data integrity and service reports